Statistical analysis Triplex
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چکیده
This was performed with SPSS version 13.0 (SPSS Inc., Chicago, IL), two-sided, at significance level p=0.05; a statistical trend was defined as p≤0.1. The Mann-Whitney test was used to compare quantitative variables between two independent groups. Spearman correlations among continuous variables were computed. χ2-tests (Bonferroni-corrected) were applied for grouped/dichotomized variables. Survival was estimated by Kaplan-Meier analysis, and differences were tested by Mantel-Cox log-rank statistics; primary endpoints were tumor-related death (diseasespecific survival), death (overall survival), tumor recurrence (recurrence-free survival, R0patients only). The following variables were dichotomized: Protein level in nuclear and total extracts ratios as high levels in tumor vs. low level in tumor as compared to normal tissue, involved lymph nodes as pN0 vs. pN1-3, distant metastasis as M0 vs. M1, surgical curability as curative vs. non-curative resection (R0 vs. R1/2). Tumor characteristics
منابع مشابه
A dynamic programming algorithm for identification of triplex-forming sequences
MOTIVATION Current methods for identification of potential triplex-forming sequences in genomes and similar sequence sets rely primarily on detecting homopurine and homopyrimidine tracts. Procedures capable of detecting sequences supporting imperfect, but structurally feasible intramolecular triplex structures are needed for better sequence analysis. RESULTS We modified an algorithm for detec...
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Back in 1957, when investigators produced a triple-stranded form of DNA while studying synthetic nucleic acids, few researchers paid much attention to the discovery. However, triplex DNA was never entirely forgotton and especially since 1987 its structural and functional importance in biological systems as well as its medical applications and therapeutic potentional have been extensively studie...
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