Statistical analysis Triplex

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This was performed with SPSS version 13.0 (SPSS Inc., Chicago, IL), two-sided, at significance level p=0.05; a statistical trend was defined as p≤0.1. The Mann-Whitney test was used to compare quantitative variables between two independent groups. Spearman correlations among continuous variables were computed. χ2-tests (Bonferroni-corrected) were applied for grouped/dichotomized variables. Survival was estimated by Kaplan-Meier analysis, and differences were tested by Mantel-Cox log-rank statistics; primary endpoints were tumor-related death (diseasespecific survival), death (overall survival), tumor recurrence (recurrence-free survival, R0patients only). The following variables were dichotomized: Protein level in nuclear and total extracts ratios as high levels in tumor vs. low level in tumor as compared to normal tissue, involved lymph nodes as pN0 vs. pN1-3, distant metastasis as M0 vs. M1, surgical curability as curative vs. non-curative resection (R0 vs. R1/2). Tumor characteristics

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تاریخ انتشار 2012